金樱子药材研究进展

樊小瑞, 李娆娆, 林丽美, 廖端芳, 李春

中国药学杂志 ›› 2018, Vol. 53 ›› Issue (16) : 1333-1341.

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中国药学杂志 ›› 2018, Vol. 53 ›› Issue (16) : 1333-1341. DOI: 10.11669/cpj.2018.16.001
综述

金樱子药材研究进展

  • 樊小瑞*, 李娆娆*, 林丽美2, 廖端芳2, 李春1*
作者信息 +

Research Progress in Medicinal Parts of Rosa laevigata Michx

  • FAN Xiao-rui1, LI Rao-rao1, LIN Li-mei2, LIAO Duan-fang2, LI Chun1*
Author information +
文章历史 +

摘要

笔者对金樱子植物果实、根等用药部位的化学成分、药理作用、质量控制及开发利用等方面进行系统的综述,发现金樱子研究较为充分,营养价值较高,除常规药用外,需挖掘其潜在价值,金樱根研究相对薄弱,需明确其药效成分,加强质量控制。

Abstract

This paper mainly summarized the chemical constituents, pharmacological activities, quality control and utilization of different medicinal parts of Rosa laevigata Michx based on systematic literature research. The various pharmacological effects and rich research on the fruits of Rosa laevigata Michx made it much more attractive for development. However, the research on the roots is comparatively weak, so further studies are needed to explore the material basis and strengthen the quality control of Rosa laevigata Michx.

关键词

金樱子 / 金樱根 / 蔷薇酸 / 香陵菜酸 / 化学成分 / 药理作用

Key words

the fruit of Rosa laevigata Michx / the root of Rosa laevigata Michx / euscaphic acid / tormentic acid / phytochemistry / pharmacological effect

引用本文

导出引用
樊小瑞, 李娆娆, 林丽美, 廖端芳, 李春. 金樱子药材研究进展[J]. 中国药学杂志, 2018, 53(16): 1333-1341 https://doi.org/10.11669/cpj.2018.16.001
FAN Xiao-rui, LI Rao-rao, LIN Li-mei, LIAO Duan-fang, LI Chun. Research Progress in Medicinal Parts of Rosa laevigata Michx[J]. Chinese Pharmaceutical Journal, 2018, 53(16): 1333-1341 https://doi.org/10.11669/cpj.2018.16.001
中图分类号: R284   

参考文献

[1] Ch.P(2015) VolⅠ(中国药典2015年版. 一部)[S]. 2015:249.
[2] TANG N X, GUO Q L, TIAN S Y, et al. The summary of medicinal history andmodern research on the root of Rosa laevigata[J]. Asia-Pacific Tradit Med(亚太传统医药), 2010, 6(12):167-169.
[3] YAN H, HAN B X, WU Q Y, et al. Rapid detection of Rosa laevigata polysaccharide content by near-infrared spectroscopy[J]. Spectrochim Acta Part A, 2011, 79(1):179-184.
[4] YI Y H, WU G Q, ZHUANG C J, et al. Study on extraction of total polysaccharides from root of Rosa laevigate Michx by ultrasound[J]. Tianjin Agr Sci(天津农业科学), 2011, 17(1):25-27.
[5] ZHANG T T, LI S P, NIE L W. Separation, purification and component analysis of polysaccharide in Rosa laevigata Michx[J]. J Bio(生物学杂志), 2002,18(3):27-29.
[6] YU C H, DAI X Y, CHEN Q, et al. Hypolipidemic and antioxidant activities of polysaccharides from Rosae laevigatae Fructus, in rats[J]. Carbohydr Poly, 2013, 94(1):56-62.
[7] ZENG N, SHEN Y, LI L Z, et al. Anti-inflammatory triterpenes from the leaves of Rosa laevigata[J]. J Nat Pro, 2011, 74(4):732-738.
[8] YAN M, ZHU Y, ZHANG H J, et al. Anti-inflammatory secondary metabolites from the leaves of Rosa laevigata[J]. Bioorg Med Chem, 2013, 21(11):3290-3297.
[9] GAO P Y, WANG M, LIU X G, et al. Triterpenes from the fruits of Rosa laevigata with acetylcholinesterase and Aβ-aggregation inhibitory activities[J]. Rsc Adv, 2015, 6(3):2431-2435.
[10] WANG J Y, ZHANG G L, CHENG D L, et al. The chemical constitute from Rosa laevigata Michx[J]. Nat Pro Res Dev(天然产物研究与开发), 2001,13(1):21-23.
[11] WANG Y M, SU X J, FU Y, et al. The chemical constitute from the roots of Rosa laevigata Michx (Ⅰ)[J]. Acta Sci Nat Univ Sunyatseni(中山大学学报:自然科学版), 2016, 55(2):76-80.
[12] BI W, LI Q, GONG W H, et al. Chemical compositions of Rosa laevigata Michx[J]. J Beijing Univ Tradit Chin Med(北京中医药大学学报), 2008,31(2):110-111.
[13] FANG J M, WANG K C, CHENG Y S. Steroids and triterpenoids from Rosa laevigata[J]. Phytochemistry, 1991, 30(10):3383-3387.
[14] LI S P. Study on the chemical constitute from the roots of Rosa laevigata Michx[D]. Hefei:Anhui University, 2013.
[15] YUAN J Q, YANG X Z, MIAO J H, et al. New triterpene glucosides from the roots of Rosa laevigata Michx[J]. Molecules, 2008, 13(9):2229-2237.
[16] GAO Y, CHEN W M, LI G Y, et al. Study on the chemical constitute of Rosa laevigata Michx[J]. Chin J Chin Mat Med(中国中药杂志), 1993,18(7):426-428,447.
[17] LI Y L, DAI N H, MA G X, et al. A new triterpenic acid from the roots of Rosa laevigata[J]. Acta Pharm Sin(药学学报), 2017, 52(3):425-429.
[18] LI S, ZHAI X, WANG T, et al. Flavonoids and triterpenoids from the roots of Rosa laevigata[J]. J Mexican Chem Soc, 2014, 58(4):374-377.
[19] LIU X G, ZHANG W C, JIN M, et al. Isolation and identification of triterpenes of fruit of Rosa laevigata Michx[J]. J Shenyang Pharm Univ(沈阳药科大学学报), 2013,3(11):851-857.
[20] DAI N H, MA X, ZOU J M, et al. Triterpenoids from roots of Rosa laevigata[J]. China J Chin Mater Med(中国中药杂志), 2016, 41(12):2267-2272.
[21] DING Y, HUANG Y L, LIU J L, et al. Studies on the chemical constituents of Rosa laevigata Michx[J]. Guihaia(广西植物), 2017,37(2):255-259.
[22] DAI N H, MA G X, ZOU J M, et al. Triterpenoids from roots of Rosa laevigata[J]. Chin Tradit Herb Drugs(中草药), 2016,47(3):374-378.
[23] WU X W, GAO P Y, LI L Z, et al. Studies on the chemical constituents of Rosa laevigata Michx fruit[J]. J Pharm Prac(药学实践杂志), 2009,27(3):183-185.
[24] YAN Z Y. Comparison of flavonoids of Rosa laevigata fruits during different collecting time[D]. Hengyang:University South Chin(南华大学), 2012.
[25] YOSHIDA T, TANAKA K, CHEN X M, et al. Tannins of Rosaceous medicinal plants. V. Hydrolyzable tannins with dehydrodigalloyl group from Rosa laevigata Michx[J]. Chem Pharm Bull, 1989, 37(4):920-924.
[26] YAN G, LI S, HU J, et al. Phenolic constituents from the roots of Rosa laevigata(Rosaceae)[J]. Biochem Syst Ecol, 2014, 52(52):23-26.
[27] WU J L, WANG P, GAO P, et al. Studies on the chemical constituents in leaves of Rosa laevigata Michx[J]. J Pharm Prac(药学实践杂志), 2012,30(4):275-278.
[28] FANG J M, WANG K C, CHENG Y S. The chemical constituents from the aerial part of Rosa laevigata[J]. J Chin Chem Soc, 1991, 38(3):297-299.
[29] LI X, CAO W, SHEN Y, et al. Antioxidant compounds from Rosa laevigata fruits[J]. Food Chem, 2012, 130(3):575-580.
[30] HE R R, YAO X S, YAO N, et al. Protective effects of radix rosa laevigata against propionibacterium acnes and lipopolysaccharide-induced liver injury[J]. Biosci Biotech Biochem, 2009, 73(5):1129-1136.
[31] HUI H, TIAN S Y, GAO D Z. Compare with the content of total tannins from different preparations of Radix Rosae Laevigatae[J]. Asia-Pacific Tradit Med(亚太传统医药), 2011,7(8):33-35.
[32] QU H, FENG Z, LI Z, et al. Induction of substantial myocardial regeneration by an active fraction of the Chinese herb Rosa laevigata Michx[J]. Bmc Complem Altern Med, 2015, 15(1):1-11.
[33] TAKASHI YOSHIDA, KATSUMI TANAKA, CHEN X M, et al. Dimeric ellagitannins, laevigatins E, F and G, from Rosa laevigata[J]. Phytochem, 1989, 28(9):2451-2454.
[34] LI J Y, REN J P, FENG D M, et al. Extraction of Rosa laevigata and analysis of its fatty acid components[J]. J Chin Cereals Oils Assoc(中国粮油学报), 2012,27(7):74-76,96.
[35] WEI X Y, LU X L. Advances in the study of pharmacological action of radix acanthopanae[J]. Study Trace Elements Health,2017,34(4):80-81.
[36] ZHANG T T, NIE L W, LIU A M, et al. Studies on immune activities of Rosa laevigata Michx polysaccharide[J]. Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2005,11(4):55-58.
[37] PI J H, TANG J, HU Z T. Study on in vitro immune activity of Rosa laevigata polysaccharide[J]. West Chin J Pharm Sci(华西药学杂志), 2014,29(2):149-151.
[38] SU S G, WEI Y L, HANG Y M, et al. Effect of Rosa laevigata Michx on protein expression and rat renal function of IgA nephropathy[J]. China J Tradit Chin Med Pharm(中华中医药杂志), 2008,23(11):973-976.
[39] HUANG Y M, SHU Y Y, WEI Y L, et al. Effect of Rosa laevigata Michx on expression of MCP-1 Mrna in rat experimental IgA nephropathy model[J]. Lishizhen Med Mater Res(时珍国医国药), 2007,18(9):2154-2155.
[40] ZOU T B, XIE Q L. Anti-inflammatory effect of cherokee rose root and its effect on NO release of macrophage[J]. Guizhou Agric Sci(贵州农业科学), 2011, 39(2):148-150.
[41] PI J H, HU Z D, CAI J, et al. Studies on in vitro antioxidative activity of differet polar parts from Rosa laevigata Mickx[J]. Jiangsu Agric Sci(江苏农业科学), 2013,41(3):285-288.
[42] ZHAOY T, GUO X M, LI F Z. Anti-oxidative activity of polysaccharide from Rosa laevigata Mickx[J]. J Bio(生物学杂志), 2003,2:23-24.
[43] XIAO K J, ZHONG X K, WANG J, et al. Extraction of brown pigment from Rosa laevigata and its antioxidant activities[J]. Pharm Bio, 2011, 49(7):734-740.
[44] CHOI S J, KIM M J, HEO H J, et al. Protective effect of Rosa laevigata against amyloid beta peptide-induced oxidative stress[J]. Amyloid Inter J Exp Clin Invest, 2006, 13(1):6-12.
[45] JUNG C S, KIM M J, JIN H H, et al. Ameliorative effect of 1, 2-benzenedicarboxylic acid dinonyl ester against amyloid beta peptide-induced neurotoxicity[J]. Amyloid Inter J Exp Clin Invest, 2009, 16(1):15-24.
[46] LIU M, XU Y, HAN X, et al. Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis[J]. Molecule, 2014, 19(8):11816-11832.
[47] ZHAO L, XU L, TAO X, et al. Protective effect of the total flavonoids from Rosa laevigata Michx fruit on renal ischemia-reperfusion injury through suppression of oxidative stress and inflammation[J]. Molecules, 2016, 21(7):952-964.
[48] TAO X, SUN X, XU L, et al. Total flavonoids from Rosa laevigata Michx fruit ameliorates hepatic ischemia/reperfusion injury through inhibition of oxidative stress and inflammation in rats[J]. Nutrients, 2016,8(7):418-431.
[49] ZHOU Y, LIAO Q, LUO Y, et al. Renal protective effect of Rosa laevigata Michx. by the inhibition of, oxidative stress in streptozotocin-induced diabetic rats[J]. Mol Med Rep, 2012, 5(6):1548-1554.
[50] ZHOU J, HE X J, XIAO Q G. Inhibitive effects of Rosa laevigata on LEC apoptosis of diabetic cataract rats by increasing Bcl-2/Bax expression ratio[J]. Recent Adv Ophthalmol(眼科新进展), 2014, 34(4):314-317.
[51] LIU Y, LUO W, LUO X, et al. Effects of Rosa laevigata Michx. extract on reactive oxygen species production and mitochondrial membrane potential in lens epithelial cells cultured under high glucose[J]. Int J Clin Exp Med, 2015, 8(9):15759-15765.
[52] YU C H, DAI X Y, CHEN Q, et al. Hypolipidemic and antioxidant activities of polysaccharides from Rosae laevigatae Fructus, in rats[J]. Carbohyd Polym, 2013, 94(1):56-62.
[53] DONG D, QI Y, XU L, et al. Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats[J]. Food Funct, 2014, 5(12):3065-3075.
[54] CAO Y C, WEN H B, WU Y L, et al. Protective effect of Rosa laevigata Michx total flavonoids on vascular endothelial cellsinjury induced by hydrogen peroxide[J]. Lishizhen Med Mater Res(时珍国医国药), 2013,24(5):1159-1161.
[55] ZHANG S, QI Y, XU Y, et al. Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation[J]. Neurochem Int, 2013, 63(5):522-532.
[56] LIU Y T. The study of the preparation and biological activities of the total flavonoids from Rosa laevigata Michx fruit[D]. Dalian:Dalian Med University, 2010.
[57] SHUAI Z, LU B, XU H, et al. Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice[J]. Food Chem Toxicol, 2013, 55(3):60-69.
[58] DONG D, XU L, HAN X, et al. Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis[J]. Molecules, 2014, 19(6):7189-7206.
[59] DONG D, SHUAI Z, YIN L, et al. Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice[J]. Food Chem Toxicol, 2013, 62(6):120-130.
[60] DONG D, YIN L, YAN Q, et al. Protective effect of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced liver fibrosis in rats[J]. Nutrients, 2015, 7(6):4829-4850.
[61] PI Z Q, CAI S L, ZHEN Y C, et al. Protective effect of Rosa laevigata Michx. polysaccharide on acute hepatic injury mice[J]. Chin Agric Sci Bull(中国农学通报), 2012, 28(35):55-58.
[62] WANG Y, ZHANG L, SHEN Y Z, et al. Effect of polysaccharides of Radix Rosa Loevigata and caulis Rosa laevigata on intestinal flora of mouse[J]. Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2012, 18(20):270-272.
[63] LAI Y X, YAN H J, TIAN S Y, et al. Study on antibacterial effects of radix rosae laevigatae extract[J]. Pharm Today(今日药学), 2012,22(9):531-533.
[64] YAN H J, WANG Z W, TIAN S Y. Study on the in vitro bacteriostatic activity of different solvent extracts from caulis Rosae laevigatae[J]. Subtrop Plant Sci(亚热带植物科学), 2012,41(3):7-10.
[65] WANG Y, XIE R, CAI D Y, et al. Study on antibacterial and anti-inflammatory effects of different processed products of Rosa laevigata root and stem[J]. J Chin Med Mater(中药材), 2014, 37(8):1356-1359.
[66] XIE X M, DING X W, CHEN J Q. NO2--elemilating effects of Rosa laevigata extract in vitro experiment[J]. Food Sci(食品科学), 2001, 22(1):30-33.
[67] FENG C E, TIAN S Y. Separating and purifying polysaccharides from root of Cherokee Rose and its in vivo effect of antitumor activity[J]. Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2011, 17(6):209-212.
[68] XIAO K J, ZHANG L, LIU X H, et al. In vitro anti-tumor effects of chemically modified polysaccharides from Cherokee Rose Fruit[J]. Int J Food Eng, 2014,10(3):473-479.
[69] LUO J H, JIANG H, WU N. The effects of Rosa laevigata on the excretion of urinary protein in rats with nephrosis induced by adriamycin[J]. China Contemp Med(当代医学), 2013(10):27-28.
[70] HUANG X H, TANG X B, ZENG J, et al. A study of radix Rosa laevigata alcohol extracton anti-hypoxia effect[J]. J Gannan Med Coll(赣南医学院学报), 2003, 23(5):488-490.
[71] XU P, HU S L, LI Y Y, et al. Comparison of polysaccharide and total flavonoids contents in Rosa laevigat from different habitats[J]. China Pharm(中国药师), 2012,15(5):648-650.
[72] HU Y. Study on HPCE fingerprint chromatograms of Rosae laevigata Michx slices[J]. Asia-Pacific Tradit Med(亚太传统医药), 2014,10(18):22-23.
[73] JIANG Y C, DENG C, LI J L. The chemical constituent difference analysis of Rosae laevigata Michx in different processing methods[J]. Mod Tradit Chin Med(现代中医药), 2015,35(6):95-96.
[74] XU Y C, MA C H, WEI L X, et al. Determination of the content of 2α, 3β, 19α, 23-tetrahydroxy ursolu-12-ene-28-carboxylic acid in Jinyingzi (dried hip of Rosa laevigatae) by HPLC[J]. J Beijing Univ Tradit Chin Med(北京中医药大学学报), 2002,25(4):42-44.
[75] LI B, CHEN Y Y, LI S X, et al. Determination of total saponins content from three differensources and medicinal parts in radix et caulis rosea[C]// China Pharmaceutical Congress & China Pharmacist Workshop,2011.
[76] TAN N X, WANG S, JIANG Z L, et al. Study anti-inflammatory and antipyretic effect of extract from root and stem of Rosa laevigata Michx[J]. Mod Chin Med(中国现代中药), 2012, 14(9):19-22.
[77] ZHAO G L, ZHANG Y, WANG C, et al. Anti-inflammatory and analgesic activity of root and rhizome sample of Rosa laevigata in different regions[J]. Asia-Pacific Tradit Med(亚太传统医药), 2014, 10(19):14-17.
[78] PENG H Y, SHOU X Y, WANG T, et al. Study on immunomodulatory activity of root and rhizome of Rosa laevigata from different habitats[J]. Chin Tradit Herb Drugs(中草药), 2014, 45(13):1903-1906.
[79] SU Y Y, GUO Q L, TIAN S Y, et al. Studies on quality standard of Radix Rosae laevigatae[J]. Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2012,18(15):109-111.
[80] ZHUANG Y. Studies on the chemical constituents and quality standards from the roots of radix Rosae laevigata Michx[D]. Nanning:Guangxi Teachers Edu University(广西师范学院), 2012.
[81] CAI J T, DING Z H. Studies on thenutritire materials in Rosae laevigatae fruits[J]. Sci Tech Food Ind(食品工业科技), 1995,3:26-29.
[82] CHEN L H, TAN L Y, XIAO B, et al. A comparative study on antioxidant activities of proanthocyanidins between Rosa laevigata and grape skin[J]. Chem Ind Forest Pro(林产化学与工业), 2013,33(3):78-84.
[83] LI J Y, REN J P, FENG D M, et al. Extraction of Rosa laevigata and analysis ofits fatty acid components[J]. J Chin Cereals Oils Assoc(中国粮油学报), 2012,27(7):74-76,96.

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国家中药标准化项目-妇科千金片/胶囊标准化建设(ZYBZH-C-HVN-21)
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